1.
Chemistry
; 25(49): 11574-11580, 2019 Sep 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31407847
RESUMO
The so-called Securinega alkaloids constitute a class of tetracyclic biologically active specialised metabolites isolated principally from subtropical plants belonging to the Phyllanthaceae family. Following a strategy based on alternative hypotheses for their biosynthesis, an easy and time-efficient divergent synthesis enabled access to twelve of those alkaloids featuring (neo)(nor)securinane skeletons. Moreover, this work permitted to reassign the absolute configurations of (+)-virosineâ B and (-)-episecurinolâ A.